Metabolism of 17-Alpha-Hydroxyprogesterone Caproate by Human Placental Mitochondria
نویسندگان
چکیده
منابع مشابه
Prevention of Recurrent Preterm Delivery by 17 Alpha-Hydroxyprogesterone Caproate
From Wake Forest University, WinstonSalem, N.C. (P.J.M.); the National Institute of Child Health and Human Development, Bethesda, Md. (M.K., C.Y.S.); the Biostatistics Center, George Washington University, Rockville, Md. (E.T.); Wayne State University, Detroit (M.P.D.); the University of Tennessee, Memphis (B.S.); the University of Chicago, Chicago (A.H.M.); the University of Alabama, Birmingha...
متن کاملPrevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate.
BACKGROUND Women who have had a spontaneous preterm delivery are at greatly increased risk for preterm delivery in subsequent pregnancies. The results of several small trials have suggested that 17 alpha-hydroxyprogesterone caproate (17P) may reduce the risk of preterm delivery. METHODS We conducted a double-blind, placebo-controlled trial involving pregnant women with a documented history of...
متن کاملOBSTETRICS : Pharmacogenomics of 17 - alpha hydroxyprogesterone caproate for recurrent preterm birth prevention
OBJECTIVE—We hypothesized that genetic variation affects responsiveness to 17-alpha hydroxyprogesterone caproate (17P) for recurrent preterm birth prevention. STUDY DESIGN—Women of European ancestry with ≥1 spontaneous singleton preterm birth at <34 weeks’ gestation who received 17P were recruited prospectively and classified as a 17P responder or nonresponder by the difference in delivery gest...
متن کاملPharmacogenomics of 17-alpha hydroxyprogesterone caproate for recurrent preterm birth: a case-control study.
OBJECTIVE To compare maternal genotypes between women with and without significant prolongation of pregnancy in the setting of 17-alpha hydroxyprogesterone caproate (17-P) administration for the prevention of recurrent preterm birth (PTB). DESIGN Case-control. SETTING Three tertiary-care centres across the USA. POPULATION Women (n = 99) with ≥ 1 prior singleton spontaneous PTB, receiving ...
متن کاملProgesterone receptor polymorphisms and clinical response to 17-alpha-hydroxyprogesterone caproate.
OBJECTIVE Seventeen-alpha-hydroxyprogesterone caproate (17-OHPC) reduces recurrent preterm birth (PTB). We hypothesized that single nucleotide polymorphisms in the human progesterone receptor (PGR) affect response to 17-OHPC in the prevention of recurrent PTB. STUDY DESIGN We conducted secondary analysis of a study of 17-OHPC vs placebo for recurrent PTB prevention. Twenty PGR gene single nuc...
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ژورنال
عنوان ژورنال: Reproductive Sciences
سال: 2011
ISSN: 1933-7191,1933-7205
DOI: 10.1177/1933719111419248